Hazrat Mir Muhammad Ishaq (ra) was the son of Hazrat Mir Nasir Nawab (ra), born on 8 September 1890 in Ludhiana. He was amongst the 313 companions of the Promised Messiah (as).

In 1894, his family migrated to Qadian. 

Hazrat Mir Muhammad Ishaq (ra) had the opportunity to serve the Jamaat in various capacities. He was appointed as the Headmaster of Madrasa-e-Ahmadiyya in 1937. He also served as the Incharge of Langar Khana. He would also supervise the arrangements on the occasions of Jalsa Salana.

Hazrat Mir Muhammad Ishaq (ra) was famous for his general welfare projects as was his revered father, Hazrat Mir Nasir Nawab (ra). On 1 May 1926, Hazrat Mir Muhammad Ishaq (ra) established a care centre for orphans and needy people in the Jamaat. It was named Dar-ul-Shayookh. In this, many poor and orphaned children, and even elders, used to reside and Hazrat Mir Muhammad Ishaq (ra) would arrange for their expenses and the education of children from his own money. And he would care for them just as if they were his own loved ones. He would also arrange for the Hifz-e-Quran for the blind children. Many children of Dar-ul-Shayookh studied in Madrasa-e-Ahmadiyya, Jamia Ahmadiyya and Talim-ul-Islam High School.  

On 17 March 1944, Hazrat Mir Muhammad Ishaq (ra) passed away and was buried in Bahishti-Maqbarah Qadian.