Hazrat Nawab Muhammad Abdullah Khan (ra) was the son-in-law of Hazrat Mirza Ghulam Ahmad (as), and the son of Hazrat Nawab Muhammad Ali Khan (ra). 

Hazrat Nawab Muhammad Abdullah Khan (ra) was born on 1 January 1896 in Malir Kotla, to Hazrat Mehr-un-Nisa Begum and Hazrat Nawab Muhammad Ali Khan (ra). He was just two and a half years old when his mother passed away.

In 1901, when he was nearly six years old, he migrated to Qadian along with his father. 

Hazrat Pir Manzur Muhammad (ra) taught him Qaidah Yassarnal Quran and the Holy Quran as well. 

On 21 December 1903, on Eid-ul-Fitr, after Maghrib prayer, his Amin ceremony was held in which Hazrat Ahmad (As) also participated and led the silent prayer.

Hazrat Nawab Muhammad Abdullah Khan (ra) read the Holy Quran with a translation from Hazrat Hafiz Roshan Ali (ra), and also memorised seven parts of the Holy Quran. 

Hazrat Bhai Abdur Rahman Qadiani (ra) taught him geography and mathematics. 

Then, he joined Madrasa-e-Ahmadiyya.

Hazrat Nawab Muhammad Abdullah (ra) was an expert in hunting, and a good sportsman as well. He was a member of the Madrasa’s football team and participated in district tournaments as well. 

In 1911, Hazrat Nawab Muhammad Abdullah Khan (ra) entered Talim-ul-Islam High School, in the seventh grade. He passed the matriculation exam in 1915. Then, he got admission to the Government College, Lahore. 

On 7 June 1915, his Nikah was settled with Hazrat Nawab Amatul Hafeez Begum (ra), the daughter of Hazrat Mirza Ghulam Ahmad (as). Hazrat Maulana Ghulam Rasul Rajiki (ra)announced the Nikah. The rukhstana was held on 22 February 1917.

Hazrat Nawab Muhammad Abdullah Khan (ra) had the opportunity to serve the Jamaat in various capacities. He was a member of the sub-committee for the Jalsa Salana Qadian 1917. In 1919, he was appointed as the acting Auditor. On the occasion of Jalsa Salana Qadian 1919, he was responsible for the necessary arrangements for the guests and the preparation of the Jalsa Gah. 

From April 1919 to October 1923, at various times, he served first as Nazir Talif-o-Ishaat and then as Naib Nazir Ishaat. 

He was also a member of the first-ever Majlis-e-Shura held in 1922. In 1923, he served as the Naib Nazir in the Sigha-e-Insidad-e-Irtidad. 

He migrated to Pakistan on 26 August 1947. 

On 1 September 1947, when Hazrat Mirza Bashiruddin Mahmud Ahmad (ra), Khalifatul Masih II founded the Sadr Anjuman Ahmadiyya at Jodhamal Building (Lahore), he appointed Hazrat Nawab Muhammad Abdullah Khan (ra). He helped the Ahmadi refugees in every possible way with the utmost love and compassion in those unfortunate circumstances. 

On 18 September 1961, Hazrat Nawab Muhammad Abdullah Khan (ra) passed away, and Hazrat Mirza Bashir Ahmad M.A. (ra) led his funeral prayers. He was buried in Bahishti Maqbarah Rabwah.

Hazrat Nawab Muhammad Abdullah Khan (ra) and Hazrat Nawab Amatul Hafeez Begum (ra) were blessed with three sons and five daughters.